Synthetic Route of 40571-86-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.40571-86-6, name is Trans-2-(benzylamino)cyclohexanol, molecular formula is C13H19NO, molecular weight is 205.2961, as common compound, the synthetic route is as follows.
General procedure: In a typical reaction, 90mL dry acetonitrile solution of tetrabutylammonium tetrafluoroborate(0.1 M) as the supporting electrolyte in an undivided cell fitted with a sacrificial magnesium rod as an anode and a stainless steel grid (20 cm2) as the cathode was subjected to electrolysis at a constant current density (I = 80 mA/cm?2). The cell was cooled to ?20°C by immersing in the Lauder refrigerating system. During the electrolysis, the system was maintained under an inert atmosphere by continuous bubbling of nitrogen. The electrolysis was stopped after the formationof two equivalents of cyanomethyl anion with respect to the beta-aminoalcohol derivatives(10 mmol, Q = 193 C). Then, 1.1 equivalent of carbon disulfide is added.The solution was removed from the cooling bath and was allowed to reach room temperature and kept under continuous stirring for 12 hours to ensure completion of the reaction. The excess of acetonitrile was removed using a rotatory evaporator, the residue was washed with water and the product was extracted three times with diethyl ether. The organic layer was washed with 20mL of water and dried over anhydrous magnesium sulfate. The solvent was removed and the residue was purified by column chromatography on silica gel 60 using a mixture of ethyl acetate/hexane (3:7) as the eluent. All the products were obtained as solids. They were characterized by 1H and 13C NMR spectroscopy, IR spectroscopy, EI mass spectrometry andelementary analysis.
The chemical industry reduces the impact on the environment during synthesis 40571-86-6, I believe this compound will play a more active role in future production and life.
Reference:
Article; Medini, Hayet; Mekni, Nejib Hussein; Boujlel, Khaled; Journal of Sulfur Chemistry; vol. 36; 6; (2015); p. 653 – 659;,
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