Synthetic Route of 150192-39-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 150192-39-5, name is (2-Bromo-5-methoxyphenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows.
Preparative Example 91 Preparation of 5-methoxy-1,3-dihydro-1-hydroxy-2,1-benzoxaborole 2-bromo-5-methoxybenzylalcohol (6.5 parts; 0.03M) was dissolved in dry THF (100 ml) and cooled to -78 C. n-Butyl-lithium (26.4 ml of a 2.5M solution in hexanes ex Aldrich, 0.066M) was added over 20 minutes with stirring under a nitrogen blanket and keeping the temperature below -60 C. After stirring for a further hour at -70 C. HPLC showed the reaction to be incomplete with 20% starting material remaining. A further aliquot of n-butyl-lithium in hexanes (5 ml; 0.0125M) was added and the reactants allowed to warm to -50 C. Tributylborate (17.8 ml; 0.066M) was then added at between -70 and -50 C. with stirring under a nitrogen blanket and the reactants allowed to warm to about 20 C. Water (20 ml) was added and the pH adjusted to 10 with hydrochloric acid. After washing with diethylether, the pH of the aqueous phase was adjusted to pH 1-2 with hydrochloric acid and washed with diethyl ether. The ether extract was washed with aqueous saturated brine, dried over anhydrous magnesium sulphate and the ether evaporated to leave the product as a pale oil (3.7 parts). This was slurried with water containing a little methanol whereupon a pinkish-white solid separated which was filtered, washed with water and dried (2.0 parts) mp=110-115 C. after recrystallisation from aqueous methanol.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 150192-39-5, (2-Bromo-5-methoxyphenyl)methanol.
Reference:
Patent; Zeneca Limited; US5880188; (1999); A;,
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