Electric Literature of 79418-41-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 79418-41-0, name is 3-Amino-7-hydroxy-2H-chromen-2-one, molecular formula is C9H7NO3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
3-Amino-7-hydroxy-2H-chromen-2-one (3) (0.56 g, 31 mmol) and O-(4-formylphenyl)dimethylcarbamothioate (0.65 g, 31 mmol) were dissolved in absoluteEtOH (10 mL) and refluxed for 2 h, during which time a precipitate formed.After cooling, the solid was collected and washed with an excess of hot EtOH:yellow solid, 0.85 g, 80 %. m.p. 240-242 C; 1H NMR (DMSO-d6): delta 8.59 (s, 1H, N=C-Ar), 7.94-7.92 (d, 1H, Ar-H, J = 8.6 Hz), 7.78 (s, 1H, =C-H),7.56-7.54 (d, 1H, Ar-H, J = 8.0 Hz),7.22-7.20 (d, 1H, Ar-H, J = 8.0 Hz),6.81 (dd, 1H, Ar-H, J = 8.0, 2.0 Hz),6.75(d, 1H, Ar-H, J = 2.0 Hz), 3.36(s, 3H, N(CH3)2), 3.32 (s, 3H, N(CH3)2);13C NMR (DMSO-d6):delta 39.1, 43.3, 102.3, 112.4, 114.0, 123.9, 130.0, 130.1, 132.3, 132.4, 133.8,154.0, 156.7, 158.5, 161.1, 161.8, 186.3; m/z obsd 369.0895; calcd for [M+H]+369.4143.
According to the analysis of related databases, 79418-41-0, the application of this compound in the production field has become more and more popular.
Reference:
Article; Garcia-Beltran, Olimpo; Rodriguez, Alejandra; Trujillo, Ariel; Canete, Alvaro; Aguirre, Pabla; Gallego-Quintero, Sebastian; Nunez, Marco T.; Aliaga, Margarita E.; Tetrahedron Letters; vol. 56; 42; (2015); p. 5761 – 5766;,
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