Electric Literature of 27129-87-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.27129-87-9, name is (3,5-Dimethylphenyl)methanol, molecular formula is C9H12O, molecular weight is 136.191, as common compound, the synthetic route is as follows.
General procedure: A glass vial fitted with magnetic stirrer and a magnetic bar containing a reaction mixture of alcohol (0.1 mmol), NH4SCN (3 eq.), catalyst (5 mol%) and 2 ml of solvent. The vial was closed with rubber septum and O2 was bubbling for 15 minutes using needles. The reaction mixture was irradiated under a 23W CFL lamp for a certain time period. Reaction progress was monitored by TLC. After, completion of the reaction, a yellow solid was formed. The reaction mixture of three vials with the same content were combined and filter it through whatman filter paper. The mixture was evaporated under reduced pressure and purified by column chromatography using hexane/ethyl acetate as eluent. Further, the reaction mixture was run on a GC-MS instrument for characterisation. Yield, conversion and selectivity were calculated using following equations.
Statistics shows that 27129-87-9 is playing an increasingly important role. we look forward to future research findings about (3,5-Dimethylphenyl)methanol.
Reference:
Article; Sheriff Shah, Sk; Pradeep Singh; Tetrahedron Letters; vol. 59; 3; (2018); p. 247 – 251;,
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