Related Products of 39068-94-5 ,Some common heterocyclic compound, 39068-94-5, molecular formula is C12H19NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
EXAMPLE 1 (preferred) 1-[(3,4-dimethoxy)benzyloxymethyl]-1-phenyl-N,N-dimethyl-n-propylamine R1 =ethyl, R2 =R3 =methyl, R4 =phenyl, R5 =,4-dimethoxyphenyl, n=q=0, m=p=1. 39.3 grams of sodium (1.71 mol) are introduced into 300 grams of 2-phenyl-2-dimethylamino-1-butanol (1.55 mol) in solution in 3 liters of anhydrous dioxane. The mixture is refluxed with vigorous stirring to disperse the sodium. After 6 hours 434 grams of 3,4-dimethoxy-alpha-chlorotoluene (2.34 mol) in solution in 1 liter of anhydrous dioxane are introduced within 30 minutes; the mixture is maintained for 6 hours at the reflux temperature of the solvent. The suspension is filtered and the solvent of the filtrate is eliminated by distillation in vacuo. The residue is taken up with 2 liters of hydrochloric acid (2N) and extracted with diethyl ether. The ether phases are removed and the aqueous acid phase is made alkaline in the cold with sodium hydroxide solution (10N) in a quantity sufficient to obtain a pH value of 12. The oil formed is extracted with ether, the ether phases are washed with water and then dried over sodium sulphate and the ether is eliminated by distillation. The oily residue obtained is purified by fractionation in vacuo. B.p.0.2/0.5 =187-193 C., weight: 271 grams, yield 50%. The DL camphosulphonate of the product is prepared in ethanol and recrystallized in ethyl acetate. Yield=85%, M.p.=108 C.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 39068-94-5, 2-(Dimethylamino)-2-phenylbutan-1-ol, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Societe Industrielle de Produits de Synthese; US4301163; (1981); A;,
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