In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 42514-50-1, name is 3-Amino-3-methylbutan-1-ol, the common compound, a new synthetic route is introduced below. Application In Synthesis of 3-Amino-3-methylbutan-1-ol
3-CHLORO-N-(5-{[7-(3-CHLOROPROPOXY)-6-METHOXYQUINAZOLIN-4-YL] AMINO} PYRIDIN-2- yl) benzamide hydrochloride (1.07 g, 2.00 MMOL), 3-AMINO-3-METHYLBUTANOL (1.03 g, 10.0 mmol) and potassium iodide (32 MG, 0.2 mmol) in dimethylacetamide (2.5 ml) was heated at 80 C for 4 days. The mixture was cooled, diluted with dichloromethane (25 ml) and the solution absorbed onto silica gel. Purification by flash chromatography, eluting with dichloromethane: methanol: aqueous ammonia (100: 5: 0.5 to 100: 25 : 2), yielded 3-chloro-N- {5- [ (7- {3- [ (3-hydroxy-1, 1-dimethylpropyl) AMINO] PROPOXY}-6-METHOXYQUINAZOLIN-4- yl) AMINO] PYRIDIN-2-YL} BENZAMIDE as a pale yellow solid (804 mg, 71 % yield): IH-NMR (DMSO-d6): 10.92 (br s, 1H), 9.68 (s, 1H), 8. 80 (s, 1H), 8.48 (s, 1H), 8.29 (d, 1H), 8.19 (d, 1H), 8.08 (s, 1H), 8.00 (d, 1H), 7.88 (s, 1H), 7.66 (d, 1H), 7. 55 (dd, 1H), 7.20 (s, 1H), 4.20 (t, 2H), 3.97 (s, 3H), 3.50 (M, 2H), 2.74 (t, 2H), 1.94 (M, 2H), 1.57 (m, 2H), 1.07 (s, 6H) MS (-ve ESI): 563 (M-H)-, MS (+ve ESI): 565 (M+H)+.
The synthetic route of 42514-50-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2004/58782; (2004); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts