Application of 19819-98-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.19819-98-8, name is 2-(o-Tolyl)ethanol, molecular formula is C9H12O, molecular weight is 136.19, as common compound, the synthetic route is as follows.
General procedure: To a mixture of caffeic acid fine powder (1.0 g, 5.56 mmol, 1.0 equiv.),alcohol (5.56 mmol, 1.0 equiv.) in nitromethane (125 mL) was addedytterbium triflate (34.4 mg, 0.056 mmol, 0.01 equiv.). After 5 min inan ultrasonic bath the mixture without protective gas was stirred ona 120 C oil bath for a given time. The reaction mixture was cooled toroom temperature, washed with deionised water (30 mL), 2% NaHCO3(30 mL) and brine, dried over anhydrous Na2SO4 and evaporated underreduced pressure to give the crude product, which was purified on asilica gel column to give the compounds 1-5 and 8-30.
Statistics shows that 19819-98-8 is playing an increasingly important role. we look forward to future research findings about 2-(o-Tolyl)ethanol.
Reference:
Article; Xie, Dongsheng; Yang, Fengzhi; Xie, Jin; Zhang, Man; Liu, Wenlu; Fu, Lei; Journal of Chemical Research; vol. 38; 11; (2014); p. 695 – 700;,
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