With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.403-41-8, name is 1-(4-Fluorophenyl)ethyl Alcohol, molecular formula is C8H9FO, molecular weight is 140.16, as common compound, the synthetic route is as follows.SDS of cas: 403-41-8
Dissolve 1-(4-fluorophenyl)ethanol (1.24 g, 8.85 mmol) in n-hexane (29.5 mL),CAL-B (195 mg), vinyl acetate (1.60 mL, 17.7 mmol) and triethylamine (0.0710 mL, 0.885 mmol) were added.The reaction mixture was stirred at room temperature for 12 hours. The mixture was filtered to remove impurities and reduced pressure to remove solvent. The mixture was purified by silica gel column chromatography (n-hexane / EtOAc = 8: 1, Rf = 0.25 (n-hexane / EtOAc = 4: 1)) and purified.(S)-1-(4-fluorophenyl)ethan-1-ol (574 mg, 46%) was obtained as a colorless oil (Formula 9)
At the same time, in my other blogs, there are other synthetic methods of this type of compound,403-41-8, 1-(4-Fluorophenyl)ethyl Alcohol, and friends who are interested can also refer to it.
Reference:
Patent; ERICA Industry-University Cooperation Foundation of Hanyang University; Min Seon-jun; Kim Ju-hyeon; Chu Hyeon-a; Cho Yong-seo; Lee Jae-gyun; Bae Ae-nim; (23 pag.)KR2019/115976; (2019); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts