As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2009-83-8, name is 6-Chlorohexan-1-ol, molecular formula is C6H13ClO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Computed Properties of C6H13ClO
Chlorohexanol (71.9 mmol, 10.00 g), p-nitrophenol (86.4 mmol, 11.80 g), K2CO3 (109 mmol, 15.09 g), KI (5 mg), and DMF (80 mL) were added to a three-necked flask and refluxed at 120 C.After 6 hours of reaction, samples were taken for gas chromatography.When there is no peak of 6-chloro-1-hexanol in the gas phase, the reaction is stopped, and the mixed solution is poured into a large amount of water to obtain an off-white precipitate. After drying,Recrystallization from ethanol gave p-nitrophenoxyhexanol (Intermediate A) with a yield of about 87%.The purity by HPLC analysis was 95.2%.
With the rapid development of chemical substances, we look forward to future research findings about 2009-83-8.
Reference:
Patent; Changzhou University; Xue Xiaoqiang; Liang Kang; Jiang Bibiao; Huang Wenyan; Yang Hongjun; Jiang Qimin; Jiang Li; (20 pag.)CN110343079; (2019); A;,
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