Related Products of 4152-92-5 ,Some common heterocyclic compound, 4152-92-5, molecular formula is C8H11NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
General procedure: Step i: Ketone 1 (1 mmol), primary amine 2 (1 mmol), and a mixture of Ti(Oi-Pr)4 (3.1 mg, 1.1 mol%) in 1-(trimethylsilyl)-2-pyrrolidinone (393 mg, 2.5 mmol) were heated at 70C with shaking in a sealed vial for 6 h. Step ii: After cooling down to r.t., EtOH (2 mL) was added to the solution and it was shaken until homogenization followed by the addition of NaBH4 (68 mg, 1.8 mmol). The resulting heterogeneous mixture was left staying overnight at r.t. Then, H2O (2 mL) was added and the mixture was sonicated for 2 h at r.t. to decompose the excess of NaBH4. The product was extracted with CHCl3 (3 mL), and the organic phase was washed with H2O (3 × 7 mL), dried (Na2SO4), and evaporated to give the respective secondary amine 3. Samples with purity below 95% as determined by LC-MS or 1H NMR spectroscopy were further purified by column chromatography (SiO2,eluent A: CHCl3, eluent B: i-PrOH, a linear gradient from 0% eluent B to 100% eluent B was used).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,4152-92-5, its application will become more common.
Reference:
Article; Bogolubsky, Andrey V.; Moroz, Yurii S.; Pipko, Sergey E.; Panov, Dmitriy M.; Konovets, Anzhelika I.; Doroschuk, Roman; Tolmachev, Andrey; Synthesis; vol. 46; 13; (2014); p. 1765 – 1772;,
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