Related Products of 29055-08-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.29055-08-1, name is (2-(Methylamino)phenyl)methanol, molecular formula is C8H11NO, molecular weight is 137.179, as common compound, the synthetic route is as follows.
[00263] To a solution of 2-(N-methylamino)-benzylalcohol(b) (536 mg, 3.9 mmol) in dry dichloromethane (25 ml) and diisopropylethylamine (681 mul, 3.9 mmol) was added dropwise chloromethyl chloroformate (360 mul, 4.0 mmol) and the reaction mixture was stirred at 0° C. with occasional check of the reaction progress by t.l.c (n-hexane:ethyl acetate=2:1). After 2 h, the starting material disappeared on t.l.c and the solution was used directly for the following reaction. [00264] Step 2 [00265] To the reaction mixture were added diisopropylethylamine (900 mul, 5.0 mmol) and acetic anhydride (400 mg) and stirred for 3 h at ambient temperature. The reaction mixture was partitioned with dichloromethane (50 ml) and water (30 ml). The water layer was separated and extracted again with dichloromethane (50 ml). The combined organic layer was washed with brine (30 ml.x.2), dried over anhydrous sodium sulfate and concentrated under reduced pressure. The resulting yellowish oil was purified on a column of silica gel (wakogel C-200 10 g, eluent dichloromethane_methanol=200:1) to give the title compound(c) as colorless syrup (740 mg, 70percent). EI-MS: m/z 271(M+); 1H-NMR (270 MHz, CDCl3): delta 2.10 (3H, s), 3.30 (3H, s), 5.07-5.78 (2H, br.d), 5.60 (0.8H, d, J=5.9), 5.73 (0.8H, d, J=5.9), 5.85 (0.4H, br.s), 7.16-7.23 (1H, m), 7.37-7.49 (3H, m).
Statistics shows that 29055-08-1 is playing an increasingly important role. we look forward to future research findings about (2-(Methylamino)phenyl)methanol.
Reference:
Patent; Basilea Pharmaceutica AG; US6812238; (2004); B1;,
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