Adding a certain compound to certain chemical reactions, such as: 722-92-9, 2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: 2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol, blongs to alcohols-buliding-blocks compound. name: 2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol
To a solution of [2- (4-AMINOPHENYL)-1,] 1,1, 3,3, 3-hexafluoropropan-2-ol (Oakwood, 1.5 g, 5.8 [MMOL)] in THF (25 mL) was added lithium bis (trimethyl) amide (11.6 mL of a 1.0 M solution in THF). After stirring for 10 minutes, methyl [A-BROMOPHENYLACETATE] (1.3 g, 5.8 [MMOL)] was added. The reaction mixture was stirred at room temperature for 18 h. The mixture was diluted with ethyl acetate and washed with water and brine. The organic solution was dried [(MGS04)] and concentrated in vacuo. Purification by flash chromatography (4: 1 hexanes/EtOAc) gave the free base of the title compound. A solution of the free base in CH2CI2 (20 mL) was acidified with 4N HCI in dioxane. Hexane was added and the hydrochloride salt was collected by filtration and dried to give the title compound (50 mg, 2percent). 1H NMR (DMSO-d6) [8] 7.45 (d, 2H), 7.30 (m, 5H), 6.72 (d, 2H), 5.22 (s, [1 H),] 3.62 (s, 3H). MS (ES+) [M/Z 408 (MH+).]
At the same time, in my other blogs, there are other synthetic methods of this type of compound,722-92-9, 2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol, and friends who are interested can also refer to it.
Reference:
Patent; PHARMACIA CORPORATION; WO2003/99769; (2003); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts