In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5259-98-3, name is 5-Chloropentan-1-ol, the common compound, a new synthetic route is introduced below. Safety of 5-Chloropentan-1-ol
5-chloro-l-pentanol (12,26 g, 0,1 mol) was dissolved in dry dichloromethane (400 mL). 3,4-Dihydro-2H-pyrane (12,62 g, 0,15 mol) and pyridine toluene-4-sulphonate (1,26 g, 5 mmol) was then added and the reaction mixture was stirred magneti- cally in a nitrogen atmosphere at room temperature over night. Sodium-hydrogen-carbonate, saturated solution (150 mL) was added and the phases were separated. The aqueous phase was then extracted with dichloromethane (4 x 25 mL). The com- bined dichloromethane phases were washed with water (2 x 20 mL) and then dried (MGS04). Dichloromethane was then dis- tilled out on a rotary evaporator and yielded 19,6 g (95 percent) of a pale yellow oil. NMR indicated a pure product.
The synthetic route of 5259-98-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; AXIMED AS; WO2005/25314; (2005); A1;,
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