Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2240-88-2, name is 3,3,3-Trifluoropropan-1-ol. This compound has unique chemical properties. The synthetic route is as follows. category: alcohols-buliding-blocks
To a dried round-bottom flask, 3,5-dimethylbenzoic acid (600 mg, 4.0 mmol) was dissolved inCH2Cl2 (14 mL) and a few drops of DMF was added. Oxalyl chloride (370 L, 4.4 mmol) wasadded dropwise resulting in gas evolution. The mixture was stirred for 30 min. 3,3,3-Trifluoropropan-1-ol (460 mg, 4.0 mmol), DMAP (10 mg, 0.080 mmol) and NEt3 (1.1 mL, 8.0mmol) were dissolved in CH2Cl2 (2.0 mL) and the CH2Cl2 solution was added to the reactionmixture. The mixture was stirred at ambient temperature overnight. To the resulting mixture, H2Owas added and extracted with Et2O three times. Combined organic extracts were washed with 1MNaOH aq., 1M HCl aq. and brine and dried over MgSO4. Concentrated mixture was purified byflash column chromatography (hexane/EtOAc = 100/1 to 20/1) to give the title compound(colorless oil, 703 mg, 71percent).
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Reference:
Article; Furukawa, Takayuki; Tobisu, Mamoru; Chatani, Naoto; Bulletin of the Chemical Society of Japan; vol. 90; 3; (2017); p. 332 – 342;,
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