Reference of 7218-43-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.7218-43-1, name is 2-[2-(2-Propynyloxy)ethoxy]ethanol, molecular formula is C7H12O3, molecular weight is 144.1684, as common compound, the synthetic route is as follows.
General procedure: Freshly ground potassium hydroxide (2 eq.) was added to a cooled (0 C) solution of S1 inanhydrous DCM under a nitrogen atmosphere. The mixture was then stirred at this temperature for an hour before the slow addition of p-toluene sulfonylchloride (1.1 eq.). The reaction mixture was thenstirred at room temperature overnight before being concentrated in vacuo to give a beige oily solid.The crude product was then taken up in EtOAc (25 mL) and the resulting suspension stirred at roomtemperature for 30 minutes. The insoluble solid was removed by filtration and the filtrate concentratedin vacuo to afford S2.
The chemical industry reduces the impact on the environment during synthesis 7218-43-1, I believe this compound will play a more active role in future production and life.
Reference:
Article; Tran, Fanny; Odell, Anahi V.; Ward, Gary E.; Westwood, Nicholas J.; Molecules; vol. 18; 9; (2013); p. 11639 – 11657;,
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