Electric Literature of 5182-44-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 5182-44-5, name is 2-(3-Chlorophenyl)ethanol. A new synthetic method of this compound is introduced below.
(c) 2-(3-Chlorophenyl)ethanol (48.2 g) and paraformaldehyde (10.8 g) were mixed and warmed to 70 on an oil bath. A stream of hydrogen chloride gas was passed vigorously through the suspension for about 7 hr. The reaction mixture was then allowed to stand at room temperature overnight. Aqueous sodium hydroxide solution (100 g/100 ml) was added cautiously to the reaction mixture. After the initial reaction subsided the rest of the alkali solution was run in fast and the resulting mixture was heated at reflux on an oil bath for 2 hr. The reaction mixture was cooled and extracted into ether (3*100 ml). The ether layer was dried (sodium sulphate) and evaporated in vacuo to give the 6-chloroisochroman as an oil (46 g), which was purified by distillation in vacuo (25.1 g, b.pt. 76-80/0.6 mmHg), characterised by its nmr spectrum.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,5182-44-5, 2-(3-Chlorophenyl)ethanol, and friends who are interested can also refer to it.
Reference:
Patent; Burroughs Wellcome Co.; US4801593; (1989); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts