Electric Literature of 61439-59-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 61439-59-6, name is 2-(4-(Benzyloxy)phenyl)ethanol. A new synthetic method of this compound is introduced below.
Take 10.0 mL ionic liquid [Emim] [OSO2OE],Add 1.0 g (4.1 mmol) 4-phenoxyphenylethanol and 2.4 g (4.9 mmol) 2,3,4,6-tetra-O-acetyl-?[-0-glucopyranose trichloroacetimidate ,Nitrogen gas three times,Cool to 0 ° C,75 muL of TMSOTf (0.4 mmol) was added dropwise using a microsyringe.Keep the temperature at around 0 °C for about 0.5 hours.Then slowly increase to room temperature for 2 h.TLC detects the disappearance of alcohol raw materials,The reaction was quenched with triethylamine.The reaction solution was extracted with anhydrous diethyl ether to give the resulting glycoside.Combine the ether phase,Use a small amount of 4percent Na2CO3,Washed with saturated saline,Then add 4percent Na2SO4 to dry,The ether was removed by rotary evaporation and recrystallized from ethanol-cyclohexane to give 2-(4-benzyloxyphenyl)ethyl-(2,3,4,6-tetra-O-acetyl)-alpha-D-pyridin Glucosinolate1.83 g, milky white solid product, yield 80.1percent.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,61439-59-6, its application will become more common.
Reference:
Patent; Zaozhuang College; Zhou Fengyan; Zhang Wenzhi; Kong Xiaoyu; Yuan Yaru; Li Suwan; (12 pag.)CN107880085; (2018); A;,
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