As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2612-28-4, name is 2-Propylpropane-1,3-diol, molecular formula is C6H14O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Application In Synthesis of 2-Propylpropane-1,3-diol
(2-1) under a nitrogen atmosphere, 4-bromo-3-fluorobenzaldehyde (20.0g), 2- propyl-1,3-propanediol (11.6g) and p-toluenesulfonic acid monohydrate (0.9g ) was dissolved in toluene (100mL), while using the Dean-Stark apparatus at reflux of the solvent while removing the formed water was stirred for 4 hours. After cooling, saturated aqueous sodium bicarbonate solution (100 mL) were separated, washed with saturated brine (100 mL) and the organic layer was washed, dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure, the residue was purified by silica gel column chromatography was purified to give crude 2- (4-bromo-3-fluorophenyl) -5-propyl-1,3-dioxane (31.0g) .
With the rapid development of chemical substances, we look forward to future research findings about 2612-28-4.
Reference:
Patent; DIC Corporation; Tojo, Kenta; Tetsuo, Kusumoto; (46 pag.)CN105358538; (2016); A;,
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