Reference of 16369-21-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 16369-21-4, name is 2-(Propylamino)ethanol, molecular formula is C5H13NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
A mixture of 2-(bis{2-[(methylsulfonyl)oxy]ethyl}amino)-3,5-dinitrobenzoic acid (43) (333 mg, 0.7 mmol) and MgO (341 mg, 8.5 mmol) in CH2Cl2 ( 5 mL) was cooled to 0 C and treated with oxalyl chloride (364 muL, 4.2 mmol ) and DMF (3 drops). The mixture was stirred at 15 0C for 1 h, filtered and then treated with a solution of 2-(propylamino)ethanol (105 muL, 0.9 mmol) and triethyl amine (160 muL, 1.1 mmol) in CH2Cl2 (5 niL) The mixture was stirred at 0 C for 40 min, diluted with CH2Cl2, washed with water and aqueous solution of methane sulfonic acid. The organic layers were dried with Na2 SO4 and then concentrated under reduced pressure. The residue was then purified by flash column chromatography on silica gel eluting with CH2Cl2/MeOH (99:1) to provide 2-(2-{[(2- hydroxyethyl)(propyl)amino]carbonyl} {2-[(methylsulfonyl)oxy]ethyl}-4,6-dinitroanilino)ethyl methanesulfonate (20) (230 mg, 58 %) as a yellow gum; 1H NMR [(CDO2SO] (mixture of rotamers) 6 8.71, 8.69 (2dJ = 2.8 Hz, IH), 8.38, 8 25 (2d, / = 2.8 Hz, IH), 4.85, 4.82 (2t, J = 5.2 Hz, IH), 4.32-4.27 (m, 4H), 3.68-3.50 (m, 5H), 3.45-3.39 (m, 3H), 3.34-3.19 (m, 2H), 3.14 (2s, 6H), 1.70-1.60 (m, 2H), 0.93, 0.73 (2tJ = 7.4 Hz, 3H) HRMS(ESI) calcd for C18H29N4O12S2 [M+H]+ »/?* 557.1218: found 557.1202.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 16369-21-4, 2-(Propylamino)ethanol.
Reference:
Patent; AUCKLAND UNISERVICES LIMITED; PATTERSON, Adam, Vorn; SMAILL, Jeffrey, Bruce; DENNY, William, Alexander; WILSON, William, Robert; SYDDALL, Sophie; ASHOORZADEH, Amir; WO2010/44685; (2010); A1;,
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