The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 100058-61-5, name is 3-(Benzyloxy)cyclobutanol. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of 3-(Benzyloxy)cyclobutanol
DEAD (1.35 mL, 5.73 mmol) was added dropwsie to a solution of crude product (1s,3s)-3-(benzyloxy)cyclobutan-1-ol (1.02 g, 5.73 mmol), 3,4-difluorophenol (821 g, 6.3 mmol) and triphenylphosphine (2.26 g, 8.6 mmol) in dry tetrahydrofuran (20 mL) at 0 C. The reaction mixture was placed under nitrogen atmosphere and stirred at 80 C for 15 h. The solvent was removed under reduced pressure, and the resulting residue was purified by column chromatography on silica gel (petroleum ether/ethyl acetate = 80:1 as eluent) to get 4-(anti-3-(benzyloxy)cyclobutoxy)-1,2-difluorobenzene (1.116 g, 68% two step yield) as faint yellow oil. 1H NMR (300 MHz, CDCl3) delta 7.39-7.25 (m, 5H), 7.08-6.99 (m, 1H), 6.63-6.56 (m, 1H), 6.51-6.44 (m, 1H), 4.81-4.73 (m, 1H), 4.44 (s, 2H), 4.36-4.28 (m, 1H), 2.54-2.37 (m, 4H).
With the rapid development of chemical substances, we look forward to future research findings about 100058-61-5.
Reference:
Article; Sheng, Ren; Yang, Liu; Zhang, Yanchun; Xing, Enming; Shi, Rui; Wen, Xiaoan; Wang, Heyao; Sun, Hongbin; Bioorganic and Medicinal Chemistry Letters; vol. 28; 15; (2018); p. 2599 – 2604;,
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