Related Products of 196811-90-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 196811-90-2, name is 2-(4-(Trifluoromethoxy)phenyl)ethanol, molecular formula is C9H9F3O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
MsCl (199 mg, 1.74 mmol) was added dropwise into a mixture of 2-[4- (trifluoromethoxy)phenyl]ethan-l-ol (300 mg, 1.46 mmol), dichloromethane (10 mL), and TEA (439 mg, 4.34 mmol) at 0C in 5 min under nitrogen. The resulting solution was stirred for 12h at room temperature and concentrated under vacuum. This resulted in the title compound (410 mg, crude) as a white solid
According to the analysis of related databases, 196811-90-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; PARAZA PHARMA, INC.; BEAUMIER, Francis; DERY, Martin; LAROUCHE-GAUTHIER, Robin; CHEN, Huifen; SHORE, Daniel; VILLEMURE, Elisia; VOLGRAF, Matthew; HU, Baihua; LU, Aijun; CRIDLAND, Andrew; WARD, Stuart; (212 pag.)WO2018/96159; (2018); A1;,
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