With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.38493-59-3, name is (3-Bromo-4-methoxyphenyl)methanol, molecular formula is C8H9BrO2, molecular weight is 217.06, as common compound, the synthetic route is as follows.name: (3-Bromo-4-methoxyphenyl)methanol
On the basis of Example 1, the other steps were not changed, and the method of step (2) in Example 1 was changed to 10 gCompound B,3-bromo-4-methoxybenzyl alcohol,Adding 8.6 g of m-chlorobenzeneboronic acid,18.8 g of potassium carbonate,Urea 82.8 mg,Palladium acetate 210 mg,Isopropyl alcohol / water solvent 100mL,Stir at room temperature. Until the solid completely dissolved, remove the reaction system of oxygen, anaerobic reaction, heating,After completion of the reaction, the isopropanol and part of the water were removed under reduced pressure, and then extracted with ethyl acetate. The organic layers were combined, dried over anhydrous sodium sulfate, and the palladium salt was removed by suction filtration. , 11.46 g, yield> 95%. The overall yield of this example was 65.5%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,38493-59-3, (3-Bromo-4-methoxyphenyl)methanol, and friends who are interested can also refer to it.
Reference:
Patent; Xu Jiangping; Chen Yunfeng; Zhou Zhongzhen; (8 pag.)CN106632070; (2017); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts