Related Products of 2425-28-7 , The common heterocyclic compound, 2425-28-7, name is 2-Bromo-1-phenylethan-1-ol, molecular formula is C8H9BrO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Under room temperature, in DMSO to the proper amount of organic solvent, by adding 100mmol compounds represented by the following general formula (I) compound, 200mmol aboving (II) compound, 20mmol catalyst (to 5mmol1 – (1-ferrocene amido ethyl) – 3-isopropyl-1-imidazole Iodized salt and 15mmolCu (OTf)2(triflic acid copper) mixture), 240mmol oxydizers PhI (OAc)2, 100mmol alkali DBU and 25mmol accelerator CeCl3, then heating up to 70 C, and at this temperature the stirring reaction 5 hours;After the reaction, the reaction solution is filtered, filtrate under stirring the pH value adjusted to neutral, and then fully saturated salt water for washing, chloroform extraction 2-3 time, combined with the phase, is distilled under reduced pressure, the resulting residue over silica gel column chromatography, to volume ratio of 1:2 of the mixed solution of petroleum ether and ethyl acetate to elute, collect eluant and evaporating eliminates takes elution solvent, thereby obtaining the compound (III) variety, the yield is 95.8%.
The synthetic route of 2425-28-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Yang Xiujuan; Yang, Xiujuan; (9 pag.)CN105503672; (2016); A;,
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