Adding a certain compound to certain chemical reactions, such as: 100-37-8, 2-(Diethylamino)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: alcohols-buliding-blocks, blongs to alcohols-buliding-blocks compound. category: alcohols-buliding-blocks
11.7 g of diethylaminoethanol was dissolved in 200 ml of 10% sodium bicarbonate solution and 100 ml of acetone. 31.1 g (0.1 mol) of 5- (2,4-difluorophenyl) acetylsalicyl chloride was added to the reaction mixture. The mixture was stirred at room temperature for 3 hours. The solvent is evaporated. The residue was suspended in 500 ml of ethyl acetate. To the reaction mixture was added 200 ml of 5% sodium bicarbonate. The ethyl acetate layer was collected and washed three times with 500 ml each. The ethyl acetate solution was dried over anhydrous sodium sulfate. The sodium sulfate was removed by filtration. The reaction mixture was stirred with 6 g of acetic acid. The organic phase is evaporated. After drying, 35 g of the desired product was obtained in a yield of 88%.
The synthetic route of 100-37-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Yu Chongxi; Techfields Biochem Inc.; Yu, Chongxi; Xu, Lina; (21 pag.)CN105439877; (2016); A;,
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