Synthetic Route of 25392-41-0, Adding some certain compound to certain chemical reactions, such as: 25392-41-0, name is 4-(Chloromethyl)-7-hydroxy-2H-chromen-2-one,molecular formula is C10H7ClO3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 25392-41-0.
Take the above crude product (2g, 9.50mmol) in a 200ml single-necked flask.Add 1N NaOH solution (100ml),The solution immediately turns thick yellow,The above solution was placed in an oil bath and heated at reflux for 2 h.After the reaction,Cool to room temperatureThe pH was adjusted to 2-3 with concentrated sulfuric acid, and the resulting solution was extracted with ethyl acetate (30 ml x 4).Combine the organic phase,Wash with saturated brine (20ml x 2)Drying with anhydrous sodium sulfate,filter,The filtrate was evaporated under reduced pressure to give a tan brown columnar crystal of 1.3 g, and the crude yield was 71.2%.The above crude product (1 g, 5.20 mmol) was suspended in 10 ml of methanol.0.5ml concentrated sulfuric acid was added dropwiseAfter dripping, the temperature is increased to reflux for about 4 hours.After the reaction,Remove methanol under reduced pressureThe residual liquid is poured into 30 ml of water,Extract with ethyl acetate (20ml×3)Combine the organic phase,Wash with saturated sodium bicarbonate solution (15ml×2)Saturated brine (15ml x 2) washes,Drying with anhydrous sodium sulfate,filter,The filtrate was evaporated under reduced pressure to give a tan oil.Column chromatography (petroleum ether/ethyl acetate, 80:20, v/v) gave 0.75 g of a pale yellow solid in 70% yield.
According to the analysis of related databases, 25392-41-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; China Pharmaceutical University; Huang Wenlong; Qian Hai; Li Zheng; Wang Xuekun; Jiao Lei; Qiu Qianqian; (29 pag.)CN105017242; (2018); B;,
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