Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 402-63-1, name is 1-(3-Fluorophenyl)ethanol. A new synthetic method of this compound is introduced below., Recommanded Product: 1-(3-Fluorophenyl)ethanol
Dissolve 1- (3-fluorophenyl) ethanol (934 mg, 6.67 mmol) in n-hexane (22.2 mL),CAL-B (147 mg), vinyl acetate (1.20 mL, 13.3 mmol) and triethylamine (0.0540 mL, 0.667 mmol) were added.The reaction mixture was stirred at room temperature for 12 hours.The mixture was filtered to remove impurities and reduced pressure to remove solvent.The mixture was purified by silica gel column chromatography (n-hexane / EtOAc = 8: 1, Rf = 0.25 (n-hexane / EtOAc = 4: 1) and purified.(S) -1- (3-fluorophenyl) ethan-1-ol (403 mg, 44%) was obtained as a colorless oil (Formula 7)
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Reference:
Patent; ERICA Industry-University Cooperation Foundation of Hanyang University; Min Seon-jun; Kim Ju-hyeon; Chu Hyeon-a; Cho Yong-seo; Lee Jae-gyun; Bae Ae-nim; (23 pag.)KR2019/115976; (2019); A;,
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