Synthetic Route of 14002-80-3 ,Some common heterocyclic compound, 14002-80-3, molecular formula is C6H12O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Compound 42; 3-[4-[1-(1-(2-(1-piperidinyl)phenyl)pentyl)aminocarbonylmethyl]phenoxy]-2,2-dimethylpropanoic acid; This product was synthesized in 3 steps. Step 1; 2-(methoxycarbonyl)-2-methylpropyl 4-methylbenzenesulfonate; Methyl 3-hydroxy-2,2-dimethylpropanoate (5.0 g, 37.83 mmol) was solubilized in dichloromethane (50 ml) and triethylamine (16.0 ml, 113.5 mmol) was added. The mixture was cooled to 0 C. and p-toluenesulfonyl chloride (7.2 g, 37.83 mmol) was added portionwise. The mixture was stirred at room temperature for 4 days and was thenhydrolyzed by water (50 ml). Layers were decanted and the organic phase was washed with 1M HCl (2×50 ml) and NaClsat (2×50 ml). It was dried with magnesium sulfate, filtered and concentrated and the resulting residue was purified by silica gel chromatography (cyclohexane/ethyl acetate 8/2). Yield: 29%
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,14002-80-3, its application will become more common.
Reference:
Patent; GENFIT; US2006/79696; (2006); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts