With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.2568-33-4, name is 3-Methylbutane-1,3-diol, molecular formula is C5H12O2, molecular weight is 104.1476, as common compound, the synthetic route is as follows.name: 3-Methylbutane-1,3-diol
[0153] 3-Methylbutane-1,3-diol (3.83 g, 36.8 mmol) wasdissolved in dichloromethane (150 ml), followed by the additionoftriethylamine(6.66 mL) andmethanesulfonyl chloride(3.13 mL) at oo C. After stirring at RT for7.5 hrs, the reactionwas quenched by ethyl acetate and water, and the organiclayer was dried over anhydrous sodium sulfate. The solventwas distilled off under reduced pressure to obtain the titlecompound as a colorless oil ( 4.79 g, 72%).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,2568-33-4, 3-Methylbutane-1,3-diol, and friends who are interested can also refer to it.
Reference:
Patent; BLUEPRINT MEDICINES CORPORATION; Hodous, Brian L.; (150 pag.)US2016/31892; (2016); A1;,
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