Synthetic Route of 4845-50-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 4845-50-5, name is 1,4-Dioxane-2,3-diol. This compound has unique chemical properties. The synthetic route is as follows.
EXAMPLE 88 5,7-Dihydro-7-methyl-2,4-di-1-pyrrolidinyl-6H-pyrrolo[2,3-d]pyrimidin-6-one (VII) A stirred mixture of 4-methylamino-2,6-di-1-pyrrolidinopyrimidine (V, EXAMPLE 3, 1.235 g) in 20 ml of oxygen-free ethanol (degassed with argon for 15 minutes) is treated with 600 mg of 2,3-dihydroxy-1,4-dioxane, added in one portion. The resulting mixture is stirred at 25 in a foil-wrapped flask under nitrogen for 22 hours, then cooled to 0. The solids are isolated by filtration, washed with 2*3 ml of cold ethanol, and dried (2 hours, 0.05 mm, 40), to give the title compound, mp 172-174; IR (mineral oil) 2958, 2925, 2865, 1725, 1605, 1574, 1533, 1489, 1478, 1469, 1456, 1451, 1394, 1388, 1366, 1345, 1333, 1325, 1269, 1261, 1096, 1082, 778 and 636 cm-1; NMR (CDCl3, TMS) 3.60-3.52, 3.17 and 1.94-1.89delta; CMR (CDCl3, TMS) 176.3, 164.9, 159.7, 156.2, 82.2, 46.8, 46.4, 35.3, 25.5 and 25.2delta; MS (m/z)=288; other ions at m/z 287, 272, 259, 246, 230, 216, 190, 70 and 55.
According to the analysis of related databases, 4845-50-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; The Upjohn Company; US5502187; (1996); A;,
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