Related Products of 34231-22-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.34231-22-6, name is 3-(Aminomethyl)benzyl Alcohol, molecular formula is C8H11NO, molecular weight is 137.18, as common compound, the synthetic route is as follows.
Fmoc-OSu (38.6 g, 115 mmol) was added to a solution of [3-(amino-methyl)phenyl]methanol (S14, 16.5 g, 121 mmol) in THF (150 mL), water (75 mL) and sodium bicarbonate (20.3 g, 241 mmol) at room temperature (rt) and the reaction stirred overnight (o/n). At that point, a small sample was diluted with MeOH, acidified with a drop of HOAc, and analyzed by LC-MS, which showed the desired product with no Fmoc-OSu reagent. The reaction was acidified with 1M HCl, diluted with ethyl acetate (EtOAc), and stirred for 2 h. The white solid was filtered off, washed well with water, then EtOAc, and air dried for 3 h until a constant weight was attained. The product thus obtained, Fmoc-S14 (15.3 g), was found by LC-MS to be free of identifiable organic impurities. The aqueous layer was extracted with EtOAc (2×). The combined organic layers were washed with H2O (2×) and brine, then dried over anhydrous MgSO4. The desiccant was removed by filtration and the filtrate concentrated under reduced pressure to give additional amounts of the desired product as a white solid (34.1 g). The combined solids were triturated with ethyl acetate at reflux for a few minutes, then o/n at rt to give Fmoc-S14 in 88% yield (38.1 g).
Statistics shows that 34231-22-6 is playing an increasingly important role. we look forward to future research findings about 3-(Aminomethyl)benzyl Alcohol.
Reference:
Patent; CYCLENIUM PHARMA INC.; MACDONALD, Dwight; DUBE, Daniel; WAHHAB, Amal; THOMAS, Helmut; RICHARD, Luc; PETERSON, Mark L.; US2019/153620; (2019); A1;,
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