The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1261524-75-7, name is 3-Bromo-2-chlorobenzyl Alcohol. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 1261524-75-7
A solution of (3 -bromo-2- chlorophenyl)methanol (600 mg, 2.71 mmol), (2-chloro-3 -(4,4,5,5 -tetramethyl- 1,3 ,2-dioxaborolan-2- yl)phenyl)methanol (728 mg, 2.71 mmol), K2C03 (936 mg, 6.77 mmol) in 1,4-dioxane (9 mL) and water(2.3 mL) was purged with nitrogen for 5 mi Pd(dppf)C12.DCM (198 mg, 0.27 mmol) was added and the reaction mixture was heated at 100 C for 12 h. The reaction mixture was filtered through a pad of celite and the pad was washed with MeOH. The filtrate was concentrated to dryness and the residue was purified by silica gel column with 0-30% EtOAc in hexanes to give a product.
With the rapid development of chemical substances, we look forward to future research findings about 1261524-75-7.
Reference:
Patent; GILEAD SCIENCES, INC.; AKTOUDIANAKIS, Evangelos; APPLEBY, Todd; CHO, Aesop; DU, Zhimin; GRAUPE, Michael; GUERRERO, Juan A.; JABRI, Salman Y.; LAD, Lateshkumar Thakorlal; MACHICAO TELLO, Paulo A.; MEDLEY, Jonathan William; METOBO, Samuel E.; MUKHERJEE, Prasenjit Kumar; NADUTHAMBI, Devan; NOTTE, Gregory; PARKHILL, Eric Q.; PHILLIPS, Barton W.; SIMONOVICH, Scott Preston; SQUIRES, Neil H.; VENKATARAMANI, Chandrasekar; WANG, Peiyuan; WATKINS, William J.; XU, Jie; YANG, Kin Shing; ZIEBENHAUS, Christopher Allen; (724 pag.)WO2018/195321; (2018); A1;,
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