Related Products of 52244-70-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 52244-70-9, name is 4-(4-Methoxyphenyl)-1-butanol. A new synthetic method of this compound is introduced below.
Methanesulfonyl chloride (2.81 ml, 36.1 mmol) was added dropwise over 5 minutes to a mixture of 4-(4- methoxyphenyl)butan-1-ol (5 g, 27.7 mmol) and triethylamine (5.22 ml, 37.4 mmol) in CH2CI2 (75.0 ml, 1165 mmol) at 0 C. Stirred at 0 C for 10 minutes then slowly warmed to 20 C. After 1 h, washed with water (50 mL), HCI 2% (60 mL) and NaHC03 4% weight. (60 mL). The organic layer was dried over MgS04, filtered and concentrated to dryness to give 7.32g (102%) of the title compound.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,52244-70-9, 4-(4-Methoxyphenyl)-1-butanol, and friends who are interested can also refer to it.
Reference:
Patent; UNIVERSITE DE MONTREAL; GAREAU, Yves; GINGRAS, Stephane; CHANTIGNY, Yves; YANG, Gaoqiang; SAUVAGEAU, Guy; BACCELLI, Irene; MARINIER, Anne; (284 pag.)WO2019/84662; (2019); A1;,
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