Synthetic Route of 32707-89-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.32707-89-4, name is (3,5-Bis(trifluoromethyl)phenyl)methanol, molecular formula is C9H6F6O, molecular weight is 244.13, as common compound, the synthetic route is as follows.
Ketones: alpha-Benzylated acetamides 19 (0.14-0.35 mmol) obtained above were dissolved in anhydrous THF (2 ml). 2 equivalents of aromatic Grignard reagents or aromatic lithium reagents (0.28-0.70 mmol) were added drop-wise. The reaction mixtures were stirred at room temperature for 10 minutes before CH2Cl2 (2 ml) and MeOH (1 ml) were added to quench the reaction. The mixtures were filtered through pads of silica gel in parallel and the silica pads were rinsed with ethyl acetate. The combined filtrates were concentrated and the residues were purified by flash chromatography on silica to give ketones 20.
Statistics shows that 32707-89-4 is playing an increasingly important role. we look forward to future research findings about (3,5-Bis(trifluoromethyl)phenyl)methanol.
Reference:
Patent; Huang, Yazhong; Hu, Shuanghua; Degnan, Andrew P.; US2006/20019; (2006); A1;,
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