The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1202577-61-4, name is trans-(4-(Trifluoromethyl)cyclohexyl)methanol. This compound has unique chemical properties. The synthetic route is as follows. Quality Control of trans-(4-(Trifluoromethyl)cyclohexyl)methanol
[00173] To a mixture of oxalyl chloride (24.96 g, 13.84 mL, 197.7 mmol) in CH2C12 (250 mL) was added dropwise DMSO (20.72 g, 28 mL, 395.4 mmol) at -65 C. The mixture was stirred at -65 C for 30 min. (iraw5,-4-(trifluoromethyl)cyclohexyl)methanol (12 g, 65.9 mmol) dissolved in CH2C12 (50 mL) was added dropwise at -65 C and the mixture was stirred at -65 C for another 30 min. Triethylamine (66.4 g, 91.2 mL, 659 mmol) was added dropwise below -65 C. The mixture was stirred at -65 C for 30 min, then stirred at rt for 1.5 h. The mixture was quenched with water (200 mL) and separated. The aqueous layer was extracted with CH2C12 (2 x 300 mL). The combined organic layers were washed with water (200 mL) and brine (200 mL), dried over anhydrous sodium sulfate, filtered and concentrated under vacuum. The residue was purified by silica gel chromatography (eluting with petroleum ether: ethyl acetate = 10: 1) to give trans-4- (trifluoromethyl)cyclohexanecarbaldehyde (8.9 g, 75%) as a slight yellow oil. 1H NMR (CDCI3, 400 MHz): delta 9.70 (s, 1H), 2.16-2.65 (m, 3H), 2.04-2.12 (m, 3H), 1.00-1.39 (m, 4H).
With the rapid development of chemical substances, we look forward to future research findings about 1202577-61-4.
Reference:
Patent; VITAE PHARMACEUTICALS, INC.; CLAREMON, David, A.; DILLARD, Lawrence, Wayne; DONG, Chengguo; FAN, Yi; JIA, Lanqi; LOTESTA, Stephen, D.; MARCUS, Andrew; SINGH, Suresh, B.; TICE, Colin, M.; YUAN, Jing; ZHAO, Wei; ZHENG, Yajun; ZHUANG, Linghang; (102 pag.)WO2016/61160; (2016); A1;,
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