Application of 440-60-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 440-60-8, name is (Perfluorophenyl)methanol. A new synthetic method of this compound is introduced below.
Example 10 In a 30 ml two-necked flask were added 0.004 g of LiOH.H2O, 0.31 g of methyl 2,2-dimethyl-3-(2-methyl-1-propenyl)cyclopropanecarboxylate, 1.00 g of (2,3,4,5,6-pentafluorophenyl)methyl alcohol and 0.6 g of toluene, and the mixture was stirred for 8 hours at a toluene refluxing temperature. Analysis of the reaction mixture by a gas chromatography showed that the yield of (2,3,4,5,6-pentafluorophenyl)methyl 2,2-dimethyl-3-(2-methyl-1-propenyl)cyclopropanecarboxylate was 92% based on the starting ester.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,440-60-8, (Perfluorophenyl)methanol, and friends who are interested can also refer to it.
Reference:
Patent; Sumitomo Chemical Company, Limited; US6441220; (2002); B1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts