Related Products of 1124-63-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1124-63-6, name is 3-Cyclohexylpropan-1-ol. A new synthetic method of this compound is introduced below.
To a stirred solution of 4-nitrophenol (4) (1.30 g, 8.35 mmol) and PPh3 (3.20 g, 12.2 mmol) in THF (30.0 mL) were added diisopropyl azodicarboxylate (2.40 mL, 12.2 mmol) and 3-cyclohexyl-1-propanol (1.91 mL, 12.2 mmol) at 0 C. After stirring for 2 h at ambient temperature, the reaction mixture was quenched with H2O and then extracted with EtOAc. The combined organic layers were dried over MgSO4 and concentrated in vacuo. The residue was purified by flash column chromatography on silica gel (EtOAc : n-hexane = 1 : 24 to 1 : 15) to afford 2.23 g (91%) of 18 as a colorless oil: 1H NMR (CDCl3, 400 MHz) delta 8.15 (d, 2H, J= 7.0 Hz), 6.91 (d, 2H, J = 7.0 Hz), 3.99 (t, 2H, J = 6.6 Hz), 1.80 (quintet, 2H, J = 7.2 Hz), 1.67 (m, 5H), 1.31 (m, 2H), 1.18 (m, 4H), 0.89 (m, 2H); 13C NMR (CDCl3, 100 MHz) delta 164.3, 141.3, 125.9, 114.4, 69.3, 37.4, 33.6, 33.3, 26.7, 26.4, 26.4.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,1124-63-6, 3-Cyclohexylpropan-1-ol, and friends who are interested can also refer to it.
Reference:
Article; Jo, Jeyun; Kim, Heegyu; Oh, Ji Youn; Kim, Soyeong; Park, Yeong Hye; Choi, Hyeonjin; Jeong, Jee-Yeong; Jung, Young-Suk; Yun, Hwayoung; Bioorganic and Medicinal Chemistry Letters; vol. 29; 24; (2019);,
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