Application of 52059-53-7 ,Some common heterocyclic compound, 52059-53-7, molecular formula is C8H9FO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Intermediate 119: 1 -Methanesulfonyloxy-2-(3 -fluorophenyl)ethane Methanesulfonyl chloride (0.92mL) was added to a stirred, cooled solution of 2-(3-fluorophenyl)ethanol (1.28g) and triethylamine (2mL) in DCM (l5mL) at 0C under an atmosphere of nitrogen. On completion of the addition, the mixture was stirred at 0C for 30 minutes then at room temperature for 1.5 hours. The mixture was partitioned between DCM and 1M hydrochloric acid and the aqueous layer was extracted with DCM. The combined organic layers were dried (Na2SO4) and filtered. The filtrate was evaporated to dryness and theresidue was purified by chromatography on silica, eluting with a mixture of ethyl acetate and cyclohexane, with a gradient of 0-100% to give 1-methanesulfonyloxy-2-(3- fluorophenyl)ethane (1.92g) as a colourless oil.1007021 ?H NMR (CDC13) : 7.33-7.26 (1H, m), 7.05-6.92 (3H, m), 4.42 (2H, t), 3.06 (2H, t), 2.89 (3H, s).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,52059-53-7, its application will become more common.
Reference:
Patent; ZAFGEN, INC.; PALLIN, Thomas, David; CRAMP, Susan, Mary; DYKE, Hazel, Joan; ZAHLER, Robert; WO2014/71369; (2014); A1;,
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