Electric Literature of 33893-85-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 33893-85-5, name is 4-(Hydroxymethyl)cyclohexanol. This compound has unique chemical properties. The synthetic route is as follows.
Into a stirred mixture of 4-(hydroxymethyl)cyclohexan-1-ol (0.13 g, 1.0 mmol) and Ph3P (0.39 g, 1.5 mmol) in THF (5 mL) at 0 C. was added DIAD (0.22 g, 1.1 mmol). After 10 mins at 0 C., it was added compound from Step 1c (0.32 g, 1.0 mmol) and stirred at rt for 18 h. It was concentrated and the crude was chromatographed (silica, hexanes/EtOAc) to give the desired compounds as a mixture of two diastereomers (0.22 g, 51%). ESI-MS m/z=428.07, 430.07 [M-H]-.
According to the analysis of related databases, 33893-85-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ENANTA PHARMACEUTICALS, INC.; Qiu, Yao-Ling; Gao, Xuri; Li, Wei; Cao, Hui; Jin, Meizhong; Kass, Jorden; Peng, Xiaowen; Or, Yat Sun; (186 pag.)US2017/253609; (2017); A1;,
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