Synthetic Route of 1072-52-2, Adding some certain compound to certain chemical reactions, such as: 1072-52-2, name is 2-(Aziridin-1-yl)ethanol,molecular formula is C4H9NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1072-52-2.
Example 16 (Table 1, entry 8 and Scheme 11): Preparation of methyl 3-[N-(2- iodoethyl)-N- [2- [(methylsulfonyl)oxy] ethyl] amino] -2,6-dinitrobenzoate (27c); A stirred5 solution of methyl 3-chloro-2,6-dinitrobenzoate (25) (140 mg, 0.54 mmol) in DMF (1.5 mL) at» , room temperature was treated with NaI (405 mg, 2.7 mmol) for 5 min, then cooled to 0 0C and treated with aziridineethanol (0.15 mL, 1.87 mmol). The mixture was stirred at 30 0C for 16 h, then diluted with IN aqueous AcOH (15 mL) and extracted with EtOAc (2×15 mL). The combined organic phases were washed with water (2x), dried, and concentrated under10 reduced pressure. The residue was chromatographed on silica gel, eluting with EtOAc/petroleum ether (1:1). The middle fractions were combined and concentrated to small volume, then hexane was added to precipitate methyl 3-[N-(2-hydroxyethyl)-N-2- (iodoethyl)amino]-2,6-dinitrobenzoate (26c) (138 mg, 58%) as a yellow gum: 1H NMR [(CDj)2SO] delta 8.24 (d, J = 9.7 Hz, 1 H), 7.59 (d, J = 9.7 Hz, 1 H), 4.79 (tj = 5.2 Hz, 1 H), 3.8715 (s, 3 H), 3.71 (t, / = 7.2 Hz, 2 H), 3.53 (q, / = 5.1 Hz, 2 H), 3.40-3.33 (m, 4 H). HRMS(FAB) calcd. for C12H15IN3O7 [MH+] m/* 439.9955; found 439.9960.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1072-52-2, 2-(Aziridin-1-yl)ethanol, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; AUCKLAND UNISERVICES LIMITED; WO2008/30112; (2008); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts