Electric Literature of 10029-04-6, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 10029-04-6 as follows.
Using compound (T-4) (50.0 g) as a starting material, imidazole (28.7 g) and methylene chloride (800 ml) were placed in a reactor and cooled to 0 C.A solution of t-butyldiphenylchlorosilane (116.1 g) in methylene chloride (110 ml) was slowly added dropwise thereto, returned to room temperature and stirred for 12 hours.The reaction mixture was poured into water and the aqueous layer was extracted with dichloromethane.The organic layer formed simultaneously with water washing was dried over anhydrous magnesium sulfate.The solution was concentrated under reduced pressure and the residue was purified by silica gel chromatography (volume ratio, heptane: ethyl acetate = 10: 1) to obtain Compound (T-17) (127.4 g; 90%).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,10029-04-6, its application will become more common.
Reference:
Patent; Jieenzhi Co., Ltd.; Jieenzhi Petrochemical Co., Ltd.; Tian Zhongyuzhi; Shi Yekuangyi; Jin Tengshishang; Di Tianhekuan; (145 pag.)CN107108457; (2017); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts