Electric Literature of 2566-44-1, Adding some certain compound to certain chemical reactions, such as: 2566-44-1, name is 2-Cyclopropylethanol,molecular formula is C5H10O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2566-44-1.
To a solution of oxalyl chloride (7.4 mL, 87 mmol) in DCM (100 mL) was added DMSO (12.4 mL, 174 mmol) dropwise at -78C and the solution was stirred at -78C for 15 minutes, then to the reaction solution was added cyclopropyl ethylalcohol (5 g, 58 mmol, dissolved in DCM lOmL). After being stirred at -78C for 1 hour, to the reaction solution was added TEA (40.4 ml, 290 mmol). The reaction solution was allowed to warm to room temperature and stirred for another 30 minutes. The reaction was quenched with water (50 ml) and extracted with DCM (50 mL) three times. The organic phase was combined, washed with saturated NH4CI solution, water and brine, and dried over anhydrous Na2SO4. The organic layer was concentrated and the residue was fractionally distilled to give 2-cyclopropylacetaldehyde (compound 23a) 1.3 g as a colorless oil. Compound 23a: 1H NMR (400 MHz, DMSO-d6) delta ppm: 9.64 – 9.76 (m, 1 H), 2.28 – 2.37 (m, 2 H), 0.89 – 0.98 (m, 1 H), 0.51 (dd, J = 8.16, 1.63 Hz, 2 H), 0.14 (dd, J = 4.83, 1.44 Hz, 2 H).
According to the analysis of related databases, 2566-44-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; FENG, Song; LIU, Haixia; WU, Guolong; YUN, Hongying; CHEN, Dongdong; LI, Chao; (102 pag.)WO2016/55553; (2016); A1;,
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