Reference of 10535-17-8 , The common heterocyclic compound, 10535-17-8, name is 1-(3,4-Dimethoxyphenyl)-2-(2-methoxyphenoxy)propane-1,3-diol, molecular formula is C18H22O6, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
The reaction was carried out in a glove box, and lignin dimer 3 (0.1 mmol, 33.4 mg) and photocatalyst lanthanum triflate (5 mol%) were weighed.Auxiliary tetrabutylammonium chloride (5mol%),Nitrogen source di-tert-butyl azodicarboxylate (1 mmol) and 2.0 mL of pyridine were placed in a 10 ml pressure-resistant tube.The reaction pressure tube is sealed and placed under a purple lamp at 380 nm.After stirring for 24 hours, after the lignin dimer 3 is completely converted,After separation by silica gel column chromatography (ethyl acetate: petroleum ether = 1:5, volume ratio), product 3,4-dimethoxybenzaldehyde (13.4 mg, yield 81%)And 1-[1-(2-methoxy)phenoxyethanol]-1,2-dicarboxylic acid diisopropyl ester-oxime(3) (28.3 mg, yield 71%).
The synthetic route of 10535-17-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Jilin University; Zhang Yuetao; He Jianghua; Wang Yinling; (11 pag.)CN110156581; (2019); A;,
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