Sources of common compounds:

Synthetic Route of 100-37-8, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 100-37-8 as follows.

Preparation of diethylaminoethyl 5-(2,4-difluorophenyl) salicylate.AcOH [39] 11.7 g (0.1 mol) of diethylaminoethanol was dissolved in 10% sodium bicarbonate (200 ml) and acetone (100 ml). 31.1 g (0.1 mol) of 5-(2,4-difluorophenyl) acetylsalicyl chloride was added into the reaction mixture. The mixture is stirred for 3 hours at RT. The solvents are evaporated off. The residue is suspended in ethyl acetate (500ml). 5% sodium bicarbonate (200 ml) is added into the reaction mixture with stirring. Ethyl acetate layer is collected and washed with water ( 3 x 500 ml). The ethyl acetate solution was dried over anhydrous sodium sulfate. Sodium sulfate is removed by filtration. 6 g of acetic acid is added into the reaction mixture with stirring. The organic solution was evaporated off. After drying, it yielded 36 g of the desired product (88%). Hygroscopic product; Solubility in water: 400 mg/ml; Elementary analysis: C H F NO5; MW: 409.42. Calculated % C: 61.60; H: 6.15; F: 9.28; N: 3.42; O: 19.54; Found % C: 61.56; H: 6.18; F: 9.27; N: 3.40; O: 19.59. 1H-NMR (400 MHz, CDCl3): delta: 1.56 (t, 6H), 2.21 (s, 3H), 3.27 (m, 4H), 3.70(m, 2H), 4.69 (t, 2H), 4.9 (b, IH), 6.74 (m, IH), 6.84 (m, IH), 7.0 (b, H), 7.06 (b, IH), 7.15 (m, IH), 7.44 (m, IH), 7.86 (m, IH).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,100-37-8, its application will become more common.

Reference:
Patent; TECHFIELDS BIOCHEM CO. LTD; YU, Chongxi; WO2008/12603; (2008); A1;,
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