Extracurricular laboratory: Synthetic route of (3-Methoxyphenyl)methanol

At the same time, in my other blogs, there are other synthetic methods of this type of compound,6971-51-3, (3-Methoxyphenyl)methanol, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 6971-51-3, (3-Methoxyphenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Product Details of 6971-51-3, blongs to alcohols-buliding-blocks compound. Product Details of 6971-51-3

A. m-Methoxybenzyl chloride To an ice cooled well stirred solution of 50 g. of m-methoxybenzyl alcohol in 500 ml. of benzene there are added, over the period of 20 minutes, 29 ml. of thionyl chloride in 40 ml. of benzene. At the end of an additional 30 minutes the ice bath was removed and the solution allowed to stand for 2 hours. Following this, the mixture was heated at reflux until the evolution of gas has ceased (30 minutes). The solvent was then removed in vacuum and the product distilled at 1.5 mm. There was obtained 39.94 g. of m-methoxybenzyl chloride, b.p. 63-69 C.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,6971-51-3, (3-Methoxyphenyl)methanol, and friends who are interested can also refer to it.

Reference:
Patent; The Upjohn Company; US3947520; (1976); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts