With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.79418-41-0, name is 3-Amino-7-hydroxy-2H-chromen-2-one, molecular formula is C9H7NO3, molecular weight is 177.1568, as common compound, the synthetic route is as follows.Recommanded Product: 79418-41-0
A portion of 7-diethylaminocoumarin-3-aldehyde (247 mg, 1 mmol) and 3-amino-7-hydroxycoumarin (195 mg, 1.1 mmol) were combined in hot absolute ethanol (20 mL) to yield a scarlet precipitate for a moment. The solution was stirred under reflux conditions for 6 h, and the precipitate was filtrated, washed with hot absolute ethanol three times, then recrystallized with DMF/H2O (v/v, 1/3) to get scarlet crystal L (347 mg, 0.86 mmol) in 86% yield. IR (KBr, cm-1): 2966, 2927, 1718, 1620, 1349, 1506, 1456, 1420, 845, 811, 770, 729, 693. 1H NMR (DMSO-d6, 400 MHz, delta): 10.54(s, 1H, OH), 9.04(s, 1H, NCH), 8.56(s, 1H, ArH), 7.81(s, 1H, ArH), 7.70(d, 1H, J = 12 Hz, ArH), 7.58(d, 1H, J = 8 Hz, ArH), 6.81 (t, 1H, J = 8 Hz, ArH), 6.77 (s, 1H, ArH), 6.61(s, 1H, ArH), 3.49(q, 4H, J = 8 Hz, CH2CH3), 1.16(t, 6H, J = 8 Hz, CH2CH3). Anal. Calcd for C23H20N2O5: C 68.31%, H 4.98%, N 6.93%, Found: C 68.55%, H 5.04%, N 6.66%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,79418-41-0, 3-Amino-7-hydroxy-2H-chromen-2-one, and friends who are interested can also refer to it.
Reference:
Article; Wang, Lingyun; Ye, Decheng; Cao, Derong; Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy; vol. 90; (2012); p. 40 – 44;,
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