Application of 6338-55-2 ,Some common heterocyclic compound, 6338-55-2, molecular formula is C6H15NO3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
See FIG. 22 for the synthesis of DBCO-PEG-OH (compound [IV]). To a solution of 2- (2- (2-aminoethoxy) ethoxy) ethan-1-ol (compound [I], 0.267 g, 1.789 mmol) in 2 ml anhydrous DCM at RT was added DBCO- (Compound [II], 0.24 g, 0.596 mmol) in DMF (5 mL) was slowly added.After the addition is complete,The reaction solution was stirred for 2 hours at RT. HPLC showed complete disappearance of the succinimide. The reaction was maintained in the dark at -20 C in the freezer.The next morning,The reaction solution was warmed below RT and diluted with 3 ml DCM.Silica gel (5 g) was added and the slurry was evaporated to dryness on a rotary evaporator.Loading the remaining powder onto the ISCO loading cartridge,Purification by column chromatography (12 g silica gel column, 5-20% methanol / DCM)0.2 g of DBCO-PEG-OH (compound [IV]) was obtained. Yield: 77%
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,6338-55-2, its application will become more common.
Reference:
Patent; Roseuwel Bio Tekeu Nol Ro Jiseu In Kopo Lei Tideu; Me Ri-meon-bae-ri-el; Ga I-jeo-tim; Mol Ra-pol-deo-beul-yu; Ra I-deu-a-us-de-ril; (101 pag.)KR2019/34320; (2019); A;,
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