Adding a certain compound to certain chemical reactions, such as: 927-74-2, 3-Butyn-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: alcohols-buliding-blocks, blongs to alcohols-buliding-blocks compound. category: alcohols-buliding-blocks
(But-3-yn- 1 -yloxy) (tert-butyl)dimethylsilane (3.5) [00139] Compound 3.5 was synthesised using a similar procedure by Nadeau et al. To a solution of 3-butyn-1 -ol (3.00 g, 42.8 mmol) in dichloromethane (60 mL) was added imidazole (7.28 g, 107 mmol) and cooled to 5 C. tert-Butyldimethylsilyl chloride (6.45 g, 42.8 mmol) was added and the reaction mixture was stirred at 25 C for 1 6 hours. Dichloromethane (100 mL) was added and the mixture was washed with water (2 x 50 mL) and brine (50 mL). The organic layer was dried over magnesium sulfate, filtered and concentrated in vacuo to afford compound 3.5 (7.73 g, 98%) as a colourless oil. 3.5: C10H20OSi (Mr 184.35); 1H NMR (400 MHz, CDCI3) O (ppm) 3.74 (t, J=7.1 Hz, 2H), 2.40 (td, J= 7.1, 2.7 Hz, 2H), 1 .95 (t, J= 2.7 Hz, 1 H), 0.90 (5, 9H),0.07 (5, 6H); 13C NMR (101 MHz, CDCI3) O (ppm) 81.6, 69.4, 61.9, 26.0, 23.0,18.4, -5.2. Does not ionise in ESI-MS. Nb. 1H NMR was consistent with literature data.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,927-74-2, 3-Butyn-1-ol, and friends who are interested can also refer to it.
Reference:
Patent; WANG, Bing, Hui; KRUM, Henry; SCAMMELLS, Peter; VINH, Natalie; SIMPSON, Jamie; CHALMERS, David; (148 pag.)WO2016/29263; (2016); A1;,
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