Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 27646-80-6, name is 2-Methyl-2-(methylamino)propan-1-ol. A new synthetic method of this compound is introduced below., Formula: C5H13NO
A slurry of the product of example 81a (215 mg) in dichloromethane (2 ml) was treated with oxalylchloride solution (400 mul 2M in dichloromethane). A drop of DMF was added. The mixture was stirred at room temperature for 1 h. The reaction mixture was concentrated in vacuo, and redissolved in dichloromethane (2 ml). This solution was treated with 2-methyl-2-methylamino-propan-l-ol (175 mg; prepared in a similar manner as described by S. G. Kuznetsov, A.V. Eltsov, J. Gen. Chem. USSR, 32, 502 (1962)) and stirred for 1 h at room temperature. The reaction mixture was poured into an aqueous NaHCOs solution (5percent) and was extracted with ethyl acetate. The organic layer was dried (MgSO4), filtered and concentrated in vacuo. The residue was triturated with heptane/ethyl acetate to provide crystalline material.Yield: 80 mg. Mp 114-1160C; LC/MS-ESI: [M+H]+ = 476.5; hFSHRago (CHO luc) EC50 = 6.0 nM
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Reference:
Patent; N.V. ORGANON; WO2009/98283; (2009); A1;,
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