With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.623-04-1, name is (4-Aminophenyl)methanol, molecular formula is C7H9NO, molecular weight is 123.1525, as common compound, the synthetic route is as follows.Quality Control of (4-Aminophenyl)methanol
The specific process is: 4-aminobenzyl alcohol (1.48g, 12mmol) with 4N sulfuric acid (15mL) is dissolved, and cooled to 0 C. then sodium nitrite (1.66 g, 24 mmol) was dissolved in water (10 mL) and dissolved, and then added dropwise. after controlling the temperature at 0 C for 30 min. sodium azide (2.34 g, 36 mmol) was dissolved in water (10 mL), and added dropwise to the above reaction solution, and slowly warmed to room temperature for 1 h. After completion of the reaction, the mixture was extracted with ethyl acetate. The organic phase was combined, and the organic phase was washed with a saturated sodium chloride solution, and the organic phase was dried over anhydrous sodium sulfate. Purified with petroleum ether / 0-10% ethyl acetate)The product was obtained as a yellowish solid, 4-azidobenzyl alcohol, yield 90%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,623-04-1, (4-Aminophenyl)methanol, and friends who are interested can also refer to it.
Reference:
Patent; Hezhou College; Zhu Dongjian; Ren Aishan; Cai Wen; Duan Zhenhua; (20 pag.)CN109134344; (2019); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts