Introduction of a new synthetic route about 5-Bromo-2-methoxybenzyl alcohol

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 80866-82-6, 5-Bromo-2-methoxybenzyl alcohol, other downstream synthetic routes, hurry up and to see.

Application of 80866-82-6, Adding some certain compound to certain chemical reactions, such as: 80866-82-6, name is 5-Bromo-2-methoxybenzyl alcohol,molecular formula is C8H9BrO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 80866-82-6.

Example 89:[2-Methoxy-5-[4-(methylsulfonylmethyl)-6-morpholin-4-yI-pyrimidin-2- yl] phenyl] methanolA mixture of 5-bromo-2-methoxybenzylalcohol (250 mg), potassium acetate (339 mg) and bis(pinacolato)diboron (352 mg) in 1,4-dioxane (10 mL) was degassed for 5 minutes. 1,1′- Bis(diphenylphosphino)fe?Ocenedichloropalladium(II) dichloromethane adduct (57 mg) was added and the reaction was heated to 8O0C for 3 hours. 2-Chloro-4~ (methylsulfonylmethyl)-6-morpholin-4-yl-pyrimidine (337 mg), ethanol (0.75 mL), a 2M solution of sodium carbonate (2.7 mL) and additional 1,1′- bis(diphenylphosphino)ferrocenedichloropalladium(II) dichloromethane adduct (57 mg) were added and the heating was continued for a further 66 hours. The reaction mixture was cooled and concentrated in vacuo. The residue was partitioned between ethyl acetate (50 mL) and water (50 mL) and filtered. The organic phase was dried (MgSO4), concentrated in vacuo and chromatographed on silica, eluting with 5% methanol in DCM. The chromatography was repeated and the residue triturated with diethyl ether to give the desired compound as a white solid (158 mg). Mass Spectrum; MH+ 394 NMR Spectrum: 1H NMR (DMSOd6) delta3.23 (3H, s), 3.73 – 3.74 (8H, m), 3.84 (3H, d), 4.51 (2H, s), 4.54 (2H, d), 5.08 (IH, t), 6.83 (IH, s), 7.00 – 7.06 (IH, m), 8.23 – 8.26 (IH, m), 8.41 (IH, d)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 80866-82-6, 5-Bromo-2-methoxybenzyl alcohol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2007/80382; (2007); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts